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Dose-Finding Designs for Early-Phase Cancer Clinical Trials

- A Brief Guidebook to Theory and Practice
Af: Akihiro Hirakawa, Shigeyuki Matsui, Takashi Daimon Engelsk Paperback

Dose-Finding Designs for Early-Phase Cancer Clinical Trials

- A Brief Guidebook to Theory and Practice
Af: Akihiro Hirakawa, Shigeyuki Matsui, Takashi Daimon Engelsk Paperback
Tjek vores konkurrenters priser
This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.
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This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.
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Se mere i:
Produktdetaljer
Sprog: Engelsk
Sider: 133
ISBN-13: 9784431555841
Indbinding: Paperback
Udgave:
ISBN-10: 4431555846
Kategori: Kliniske forsøg
Udg. Dato: 31 maj 2019
Længde: 12mm
Bredde: 235mm
Højde: 155mm
Forlag: Springer Verlag, Japan
Oplagsdato: 31 maj 2019
Forfatter(e): Akihiro Hirakawa, Shigeyuki Matsui, Takashi Daimon
Forfatter(e) Akihiro Hirakawa, Shigeyuki Matsui, Takashi Daimon

Kategori Kliniske forsøg

ISBN-13 9784431555841

Sprog Engelsk

Indbinding Paperback

Sider 133

Udgave

Længde 12mm

Bredde 235mm

Højde 155mm

Udg. Dato 31 maj 2019

Oplagsdato 31 maj 2019

Forlag Springer Verlag, Japan