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Statistics in Clinical and Observational Vaccine Studies

Af: Jozef Nauta Engelsk Paperback

Statistics in Clinical and Observational Vaccine Studies

Af: Jozef Nauta Engelsk Paperback
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This book offers an overview of the statistical methods used in clinical and observational vaccine studies. Pursuing a practical rather than theoretical approach, it presents a range of real-world examples with SAS codes, making the application of the methods straightforward.

This revised edition has been significantly expanded to reflect the current interest in this area. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the analysis of immunogenicity data. Discussed are, amongst others, maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of data of equivalence, and non-inferiority immunogenicity studies. Other topics covered include fitting protection curves to data from vaccine efficacy studies, and the analysis of vaccine safety data.

In addition, the book features four new chapters on vaccine field studies: an introductory one, one on randomized vaccine efficacy studies, one on observational vaccine effectiveness studies, and one on the meta-analysis of vaccine efficacy studies.

The book offers useful insights for statisticians and epidemiologists working in the pharmaceutical industry or at vaccines institutes, as well as graduate students interested in pharmaceutical statistics.

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This book offers an overview of the statistical methods used in clinical and observational vaccine studies. Pursuing a practical rather than theoretical approach, it presents a range of real-world examples with SAS codes, making the application of the methods straightforward.

This revised edition has been significantly expanded to reflect the current interest in this area. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the analysis of immunogenicity data. Discussed are, amongst others, maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of data of equivalence, and non-inferiority immunogenicity studies. Other topics covered include fitting protection curves to data from vaccine efficacy studies, and the analysis of vaccine safety data.

In addition, the book features four new chapters on vaccine field studies: an introductory one, one on randomized vaccine efficacy studies, one on observational vaccine effectiveness studies, and one on the meta-analysis of vaccine efficacy studies.

The book offers useful insights for statisticians and epidemiologists working in the pharmaceutical industry or at vaccines institutes, as well as graduate students interested in pharmaceutical statistics.

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Se mere i:
Produktdetaljer
Sprog: Engelsk
Sider: 234
ISBN-13: 9783030376956
Indbinding: Paperback
Udgave:
ISBN-10: 3030376958
Kategori: Kliniske forsøg
Udg. Dato: 15 mar 2021
Længde: 0mm
Bredde: 155mm
Højde: 235mm
Forlag: Springer Nature Switzerland AG
Oplagsdato: 15 mar 2021
Forfatter(e): Jozef Nauta
Forfatter(e) Jozef Nauta

Kategori Kliniske forsøg

ISBN-13 9783030376956

Sprog Engelsk

Indbinding Paperback

Sider 234

Udgave

Længde 0mm

Bredde 155mm

Højde 235mm

Udg. Dato 15 mar 2021

Oplagsdato 15 mar 2021

Forlag Springer Nature Switzerland AG