This volume is being published at a critical time in U.S. history and serves as a comprehensive and much-needed update to what is known about Latinx health. As both the United States and Latinx subgroups experience demographic shifts, it is critical to examine the current epidemiology of Latinx health, as well as the factors influencing the health and well-being of this growing population. Chapters in this book, written by highly respected experts, illuminate the diversity of the Latinx population and provide strategies to mitigate many of the challenges they face, including challenges related to migrating to new destinations. The book is designed to enrich dialogue around the multilevel determinants of Latinx health and concludes with a call to action for increased culturally congruent, theoretically informed and participatory Latinx health research. The book also encourages the mentorship and growth of early career and junior investigators to conduct research on Latinx health issues.A selection of the perspectives included among the chapters: Chronic disease and mental health issues in Latinx populationsSubstance use among Latinx adolescents in the United StatesPhysical and intellectual and developmental disabilities in Latinx populationsHealth insurance reform and the Latinx populationImmigration enforcement policies and Latinx healthResearch priorities for Latinx sexual and gender minoritiesRacial and ethnic discrimination, intersectionality, acculturation, and Latinx health New and Emerging Issues in Latinx Health is an invaluable compendium that provides a foundation of understanding Latinx health and well-being and guides future research and practice. The book is essential for researchers, practitioners, and students in the fields of public health and the social sciences including community and health psychology, health administration and policy, community health education, medical anthropology, medical sociology, population health, and preventive medicine. Moreover, the chapters in this volume are also relevant for federal, state, and local agencies, including health departments, and other Latinx- and immigrant-serving community organizations.