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Protein Kinase C

- Emerging Roles and Therapeutic Potential
Engelsk Paperback

Protein Kinase C

- Emerging Roles and Therapeutic Potential
Engelsk Paperback
Tjek vores konkurrenters priser
In this compilation, the authors review the structural basis of PKC isozymes and focus on the C1 domain, as well as the plausible binding mechanisms of its activators. Additionally, the recent molecular dynamics simulation studies of how phorbol esters or bryostatin bind to the activator pocket are described and some of the key amino acid residues recently identified as important for activator binding are investigated. The following chapter focuses on the expression pattern and function of PKCα in cancer cells, and newly emerging PKCα-targeted cancer therapies. PKCα acts directly and/or indirectly in various signaling mechanisms in cancer cells, including proliferation, survival, invasion, migration, apoptosis and drug resistance. A final review is provided which dissects the crosstalk between p53 and PKCδ in the context of apoptotic cell death and cancer therapy. PKCδ is implicated in a transcriptional regulation of the p53 tumor suppressor that is critical for cell cycle arrest and apoptosis in response to DNA damage.
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In this compilation, the authors review the structural basis of PKC isozymes and focus on the C1 domain, as well as the plausible binding mechanisms of its activators. Additionally, the recent molecular dynamics simulation studies of how phorbol esters or bryostatin bind to the activator pocket are described and some of the key amino acid residues recently identified as important for activator binding are investigated. The following chapter focuses on the expression pattern and function of PKCα in cancer cells, and newly emerging PKCα-targeted cancer therapies. PKCα acts directly and/or indirectly in various signaling mechanisms in cancer cells, including proliferation, survival, invasion, migration, apoptosis and drug resistance. A final review is provided which dissects the crosstalk between p53 and PKCδ in the context of apoptotic cell death and cancer therapy. PKCδ is implicated in a transcriptional regulation of the p53 tumor suppressor that is critical for cell cycle arrest and apoptosis in response to DNA damage.
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Se mere i:
Produktdetaljer
Sprog: Engelsk
Sider: 83
ISBN-13: 9781536132106
Indbinding: Paperback
Udgave:
ISBN-10: 1536132101
Kategori: Biokemi
Udg. Dato: 1 feb 2018
Længde: 0mm
Bredde: 155mm
Højde: 230mm
Forlag: Nova Science Publishers Inc
Oplagsdato: 1 feb 2018
Forfatter(e):
Forfatter(e)

Kategori Biokemi

ISBN-13 9781536132106

Sprog Engelsk

Indbinding Paperback

Sider 83

Udgave

Længde 0mm

Bredde 155mm

Højde 230mm

Udg. Dato 1 feb 2018

Oplagsdato 1 feb 2018

Forlag Nova Science Publishers Inc