This book presents a comprehensive overview of the traditional and modern analytical methods utilized in the sample preparation of various matrices for the extraction, clean-up, detection, and quantification of pesticide residues in soil, water, and food commodities. It also covers some Quenchers methods, which are a type of extraction cum clean-up technique. The book provides a brief history of pesticide development, as well as information on the modern pesticides and metabolic pathways of selected xenobiotics from different groups of pesticides, which helps to understand the basic nature of pesticides. The latest analytical techniques, such as TLC, GLC, HPLC, HPTLC, super critical extraction, and chromatography, are discussed in a simple and concise manner. The book details the sampling extraction, clean-up, and solid phase extraction techniques for residue analysis, and it also outlines the recently developed multi-residue methods in a separate chapter. The book has been updated with the help of a number of standard reference books and research papers, giving it a modern and relevant touch. A glossary of pesticide residue terms is included, which can be extremely helpful for beginners in this field. This book will provide students with a solid background in pesticides, their metabolism, and various techniques for estimating residues of toxic xenobiotics in all components of the environment. In conclusion, this book serves as an excellent resource for knowledge seekers, including students and research workers, and it will prove highly valuable to all those who are engaged in the area of pesticides.